Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates
نویسندگان
چکیده
منابع مشابه
FREQUENCY OF C3435 MDR1 AND A6896G CYP3A5 SINGLE NUCLEOTIDE POLYMORPHISM IN AN IRANIAN POPULATION AND COMPARISON WITH OTHER ETHNIC GROUPS
ABSTRACT Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the ...
متن کاملfrequency of c3435 mdr1 and a6896g cyp3a5 single nucleotide polymorphism in an iranian population and comparison with other ethnic groups
abstract background: it is well recognized that different patients respond in different ways to medications. the inter-individual variations are greater than the intera- individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. the recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the h...
متن کاملLack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epilepsy
The variability of P-glycoprotein expression in individuals is linked to a C3435T polymorphism of the multidrug-resistance 1 (MDR1) gene, and the CC genotype at the C3435T polymorphism was reported to be associated with multidrug resistance in epilepsy patients. Since population frequencies of polymorphic genes depend on ethnic specificity, we investigated functional significance of the C3435T ...
متن کاملFrequency of C3435 Mdr1 and A6896g Cyp3a5 Single Nucleotide Polymorphism in an Iranian Population and Comparison with Other Ethnic Groups
Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera-individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the hypothesis ...
متن کاملfrequency of m287t/as3mt single nucleotide polymorphism in an iranian population
background : to determine the frequency of the single nucleotide polymorphism m287t in exon 9 of the as3mt gene in iranian population and to assess the difference in allele frequencies with other ethnicities. subjects and methods : genotyping analysis was performed on 150 healthy subjects using the pcr-rflp assay. we used chi-square analysis to check the deviation from hardy–weinberg equilibriu...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2003
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2003.01820.x